Treatment The cure of overdosage with promethazine and phenylephrine is essentially symptomatic and supportive. Only in conditions of extreme overdosage or unique sensitivity do crucial signs which include respiration, pulse, blood pressure, temperature, and EKG must be monitored. Activated charcoal orally or by lavage may be presented, or sodium or magnesium sulfate orally as being a cathartic.
As with all drug, people who find themselves using other drugs or have underlying healthcare concerns must talk to their healthcare Skilled.
Excessively huge dosages of antihistamines, including promethazine hydrochloride, in pediatric clients may possibly induce unexpected Dying (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric clients.
Known for its sedative and anti-nausea Homes, it’s Primarily helpful all through night time several hours when uninterrupted rest is crucial.
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Though Akorn cough syrup is intended for professional medical use, it has been appropriated in lean lifestyle. This leisure use is harmful and unlawful.
Phenylephrine: A study in rabbits indicated that ongoing reasonable overexposure to phenylephrine (3 mg/working day) throughout the second fifty percent of pregnancy (22nd day of gestation to delivery) may perhaps contribute to perinatal wastage, prematurity, untimely labor, And perhaps fetal anomalies; when phenylephrine (3 mg/day) was given to rabbits throughout the 1st 50 percent of pregnancy (3rd day following mating for 7 days), a substantial amount gave birth to litters of small delivery body weight.
Nonteratogenic Consequences – Promethazine administered to a pregnant female in two weeks of supply could inhibit platelet aggregation in the newborn.
Details for People Promethazine and phenylephrine may lead to marked drowsiness or may perhaps impair the psychological and/or Bodily skills needed for the overall performance of potentially harmful duties, including driving a car or functioning equipment.
Medical doctor Recommended Use: codeine bottles Needs to be utilised as directed by a healthcare supplier, specifically for little ones or Individuals with fundamental overall health ailments.
A further research confirmed that phenylephrine was connected to anomalies of aortic arch and with ventricular septal defect from the chick embryo.
As a result of threats of dependancy, abuse, and misuse with opioids, even at recommended doses [see Warnings and Safeguards (five.one)], reserve promethazine HCl and codeine phosphate oral solution for use in adult individuals for whom the advantages of cough suppression are expected to outweigh the hazards, As well as in whom an enough assessment on the etiology with the cough continues to be designed.
A research click here of the results of adrenergic medicine on ovum transportation in rabbits indicated that treatment with phenylephrine did not alter incidence of pregnancy; the number of implantations was significantly reduced when higher doses in the drug were used.